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Nothing in Common is a 1986 comedy-drama film, directed by Garry Marshall. It stars Tom Hanks and Jackie Gleason in what would prove to be Gleason's final film role; he was suffering from terminal cancer.

This film, released in 1986, wasn't a great financial success, but it became more popular as Hanks' fame grew. It is considered by some to be a pivotal role in Hanks' career because it marked his transition from less developed comedic roles to leads in more serious stories, while many critics also praised Gleason's performance.